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Identification of variants associated with sporadic thoracic aortic dissection: a case--control study

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 438-447 doi: 10.1007/s11684-020-0826-1

Abstract: We found that COL3A1 was significantly relevant to STAD (P = 7.35 × 10−6) after10 000 times permutation test (P = 2.49 × 10−3).Further bioinformatics analysis showed that COL3A1 was highly expressed in dissected aortic tissuesidentified a profile of known heritable TAD genes in the Chinese STAD population and found that COL3A1

Keywords： sporadic thoracic aortic dissection     exome sequencing     gene COL3A1     case–control study     extracellular    

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Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 808-814 doi: 10.1007/s11684-021-0878-x

Abstract: families with EB, and eight variants including a novel nonsense variant (c.47G>A, p.W16*) in LAMA3<.6187C>T, p.R2063W; c.7097G>A, p.G2366D; c.8569G>T, p.E2857*; c.3625_3635del, p.S1209fs) variants in COL7A1Notably, this study identified a nonsense variant in LAMA3 that causes EB within the Chinese populationand revealed that this variant resulted in a reduction in LAMA3 mRNA and protein expression levels

Keywords： epidermolysis bullosa     LAMA3     COL7A1     KRT5     Chinese families    

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Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 269-273 doi: 10.1007/s11684-007-0051-1

Abstract: uptake and insulin resistance in 3T3-L1 cells.Radioimmunoassay was used to determine glucose uptake in 3T3-L1 cells with different gene expression-L1 cells with different gene expression levels, including insulin receptor substrate-1(IRS-1), phosphatidylinositolThe glucose uptake decreased with the increase in gene expression in 3T3-L1 cells, which was independent, GSK-3 and p38MAPK, increased with overexpression in 3T3-L1 cells.

Keywords： 3T3-L1     influence     resistance     receptor substrate-1     transport    

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APPLE SUMO E3 LIGASE MDSIZ1 NEGATIVELY REGULATES DROUGHT TOLERANCE

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,

Abstract: MdSIZ1 is a SUMO (small ubiquitin-like modifier) E3 ligase that promotes SUMO binding to substrate proteinsHere, we demonstrate that MdSIZ1 in apple has a negative relationship with drought tolerance MdSIZ1 RNAi transgenic apple trees had a higher survival rate after drought stress.In addition, MdSIZ1 RNAi transgenic plants had a higher net photosynthetic rate duringTaken together, these results indicate that apple MdSIZ1 negatively regulates drought stress by enhancing

Keywords： apple / drought tolerance / gene expression / MdSIZ1    

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APPLE SUMO E3 LIGASE MDSIZ1 NEGATIVELY REGULATES DROUGHT TOLERANCE

Baohua CHU, Jia SUN, Huan DANG, Ziqing MA, Shuang ZHAO, Qingmei GUAN, Xuewei LI

Frontiers of Agricultural Science and Engineering   Pages 247-261 doi: 10.15302/J-FASE-2021388

Abstract: MdSIZ1 is a SUMO (small ubiquitin-like modifier) E3 ligase that promotes SUMO binding to substrate proteinsTaken together, these results indicate that apple MdSIZ1 negatively regulates drought stress by enhancing

Keywords： apple     drought tolerance     gene expression     MdSIZ1    

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Bioinformatic exploration of MTA1-regulated gene networks in colon cancer

Chunxiao Li,Haijuan Wang,Feng Lin,Hui Li,Tao Wen,Haili Qian,Qimin Zhan

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 178-182 doi: 10.1007/s11684-016-0442-2

Abstract:

Metastasis-associated gene 1 (MTA1) controls a series of biological processes in tumor progressionTumor progression is a complex process regulated by a gene network.The global cancer gene regulatory network must be analyzed to determine the position of MTA1 in the molecularnetwork and its cooperative genes by further exploring the biological functions of this gene.GO and KEGG pathway analyses were conducted with DAVID and gene network analysis via STRING and Cytoscape

Keywords： metastasis-associated gene 1     colon cancer     bioinformatics    

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NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation

Jiajia Hu, Wenbin Shen, Qian Qu, Xiaochun Fei, Ying Miao, Xinyun Huang, Jiajun Liu, Yingli Wu, Biao Li

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 646-657 doi: 10.1007/s11684-018-0643-y

Abstract: gene is thought to be a tumor-suppressor gene.Our previous study found that overexpression of gene in PC3 cell line could slow down the tumor proliferationThus, we supposed to have an “enhanced firepower” effect by combining overexpressed gene therapy andof hNIS protein in PC3 cells might be the reason for the low iodine uptake.By overexpressing in PC3, the radioactive iodine uptake ability was significantly increased.

Keywords： androgen-independent prostate cancer     normal epithelial cell-specific 1/kallikrein 10     sodium/iodide symporter    

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Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 148-152 doi: 10.1007/s11684-009-0032-7

Abstract: To investigate the regulation of tumor suppressor XAF1 gene expression in digestive system cancers, westudied XAF1 gene promoter transcription activity and mRNA level in digestive system cancer cell linesgene was amplified by polymerase chain reaction (PCR) and cloned into pGL3-basic vector and pEGFP-1 vectorshowed that the promoter transcription activity in digestive system tumor cell lines transfected with pGL3-The activities of pGL3-XAF1p in the three digestive system cancer cell lines after treatment with heat

Keywords： gene     X-linked inhibitor of apoptosis protein associated factor-1 (XAF1)     promoter     transcription regulation    

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Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: Runt-related transcription factor 1 (RUNX1) is an essential regulator of normal hematopoiesis.However, RUNX1 mutations have been largely under-explored compared with RUNX1 fusions mainlyThen, based on RNA-seq data from The Cancer Genome Atlas AML cohort, we developed a 300-gene signaturein patients with RUNX1 mutations.This study revealed the distinct gene expression pattern of RUNX1 mutations and the underlying

Keywords： RUNX1     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

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Identification of an E3 ligase-encoding gene

Yanfei Zhang, Xinchun Zhao, Yongchun Zhou, Min Wang, Guangbiao Zhou

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 318-326 doi: 10.1007/s11684-019-0708-6

Abstract: We found that silencing of one of the candidates, that encodes an E3 ubiquitin ligase essential forWe further evaluated the significance of in NSCLCs and found that this gene was more elevated in tumor

Keywords： RFWD3     NSCLC     prognosis     tobacco smoke    

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Antitumor immunity of human SART3 gene vaccine against mouse tumor

HE Yu, YANG Shuhua, LIU Yong, LI Tao

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 51-57 doi: 10.1007/s11684-008-0010-5

Abstract: To determine whether squamous cell carcinoma antigen recognized by human T cell 3 (SART3) gene can induceantitumor immunity against tumor cells which express the gene, we constructed mouse tumor cells expressinghuman SART3 (LM8-SART3) and carried out experiments .After subcutaneous injection with SART3 gene vaccine, cytotoxic T lymphocyte (CTL) activity was measuredhuman SART3 (LM8-SART3) which may provide new possibilities in antitumor therapy.

Keywords： antitumor therapy     occurrence     implantation     DNA vaccine     SART3 DNA    

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Adenovirus-mediated tissue inhibitor of metalloproteinase-3 gene transfection inhibits rabbit intervertebral

Xudong YU MM, Zengwu SHAO MD, Liming XIONG MD, Weiwei XU MM, Hezhong WANG MM, Huifa XU MM,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 415-420 doi: 10.1007/s11684-009-0072-z

Abstract: gene, Safranin O-Fast green staining, and immunohistochemical staining for TIMP-3 and type II collagenalleviated as compared with groups 1 and 2.4, and 5 than in groups 1 and 2.with group 1.The positive-staining rate in group 3 (79.42%±1.35%) was about 3times that of group 1 (25.47%

Keywords： tissue inhibitor of metalloproteinase-3     intervertebral disc     rabbit     gene therapy    

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Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression andhypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1

Frontiers of Medicine doi: 10.1007/s11684-023-1003-0

Abstract: Lipin proteins including Lipin 1–3 act as transcriptional co-activators and phosphatidic acid phosphohydrolasethe overexpression and abnormal distribution of Lipin1 in cytosol and nucleoplasm.The increased expression of Lipin1 in cytosol may contribute to TG anabolism, and the decreased Lipin1in nucleoplasm can reduce PGC1α, further leading to mitochondrial dysfunction and reduced TG catabolismOur study suggested that Lipin3 was a novel disease-causing gene inducing obesity and HTG.

Keywords： Lipin3     Lipin1     hypertriglyceridemia     obesity     mitochondrial dysfunction    

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Gene therapy for hemophilia B mice with scAAV8-LP1-hFIX

Wei Lu,Qingzhang Zhou,Hao Yang,Hao Wang,Yexing Gu,Qi Shen,Jinglun Xue,Xiaoyan Dong,Jinzhong Chen

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 212-218 doi: 10.1007/s11684-016-0438-y

Abstract: Gene therapy might be the ultimate strategy for the disease.However, two main problems that should be solved in gene therapy for hemophilia B are immunity and safetyimmunogenicity and high transfection efficiency in liver cells, might be a potential vector for hemophilia B geneA strong liver-specific promoter-1 (LP1) was inserted and mutant human FIX Arg338Ala was introduced intoOur study provides a potential gene therapy method for hemophilia B.

Keywords： hemophilia B     AAV8     hFIX     gene therapy    

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Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction with

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 217-226 doi: 10.1007/s11684-014-0326-2

Abstract: designed to investigate the contribution of miRNA-122-binding site polymorphism at the IL-1A gene and its multiplicative interactions with hepatitis B virus (HBV) mutations in the risk

Keywords： hepatocellular carcinoma (HCC)     interaction     miRNA-122-binding site     IL-1A     rs3783553     hepatitis B virus (    

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Title Author Date Type Operation

Identification of variants associated with sporadic thoracic aortic dissection: a case--control study

Journal Article

Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in

Journal Article

Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan

Journal Article

APPLE SUMO E3 LIGASE MDSIZ1 NEGATIVELY REGULATES DROUGHT TOLERANCE

Journal Article

APPLE SUMO E3 LIGASE MDSIZ1 NEGATIVELY REGULATES DROUGHT TOLERANCE

Baohua CHU, Jia SUN, Huan DANG, Ziqing MA, Shuang ZHAO, Qingmei GUAN, Xuewei LI

Journal Article

Bioinformatic exploration of MTA1-regulated gene networks in colon cancer

Chunxiao Li,Haijuan Wang,Feng Lin,Hui Li,Tao Wen,Haili Qian,Qimin Zhan

Journal Article

NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation

Jiajia Hu, Wenbin Shen, Qian Qu, Xiaochun Fei, Ying Miao, Xinyun Huang, Jiajun Liu, Yingli Wu, Biao Li

Journal Article

Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Journal Article

Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Journal Article

Identification of an E3 ligase-encoding gene

Yanfei Zhang, Xinchun Zhao, Yongchun Zhou, Min Wang, Guangbiao Zhou

Journal Article

Antitumor immunity of human SART3 gene vaccine against mouse tumor

HE Yu, YANG Shuhua, LIU Yong, LI Tao

Journal Article

Adenovirus-mediated tissue inhibitor of metalloproteinase-3 gene transfection inhibits rabbit intervertebral

Xudong YU MM, Zengwu SHAO MD, Liming XIONG MD, Weiwei XU MM, Hezhong WANG MM, Huifa XU MM,

Journal Article

Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression andhypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1

Journal Article

Gene therapy for hemophilia B mice with scAAV8-LP1-hFIX

Wei Lu,Qingzhang Zhou,Hao Yang,Hao Wang,Yexing Gu,Qi Shen,Jinglun Xue,Xiaoyan Dong,Jinzhong Chen

Journal Article

Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction with

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Journal Article